Why PRP+PDRN to the Tear Troughs?

Tear trough devolumization is one of the most noticeable signs of facial aging.
The tear trough is the anatomical junction between the lower eyelid and the cheek. Over time, as the skin and supporting tissues thin, the orbital fat can herniate forward and descend. This creates hollowness under the eyes while contributing to deepening of the nasolabial fold. Patients often first notice this change as dark circles, tired appearance, or shadowing under the eyes.

For nearly 25 years, hyaluronic acid dermal fillers have been the standard treatment for tear trough correction. Fillers remain an excellent option for restoring volume. However, a growing number of patients—particularly those seeking improvements in delicate areas like under the eyes—turn to PRP combined with PDRN as a regenerative alternative. These patients often prefer a biological approach that naturally thickens the dermis, improves epidermal health, and enhances skin texture rather than simply adding volume. PRP+PDRN can help the skin at different layers and improve the overall appearance of the skin.

As biostimulants, PRP and PDRN work synergistically to improve overall skin quality:

• PRP delivers concentrated growth factors that stimulate collagen production, reduce pigmentation, and support tissue healing.
• PDRN reduces inflammation, enhances fibroblast activity (boosting collagen, elastin, and natural hyaluronic acid), accelerates tissue repair, and strengthens the skin barrier.

Together, PRP + PDRN offer a compelling option for patients aligned with preventative and regenerative aesthetics. They are also appropriate for patients who have experienced chronic adverse effects from hyaluronic acid fillers—such as prolonged swelling or filler migration—and want an alternative that does not persist in the tissue.

Because PRP + PDRN are serum-based, they create noticeable swelling immediately after injection. This swelling can be significant, but typically resolves within 1–2 days as the body absorbs the serum. These treatments are not gels, do not migrate, and do not remain long-term in the tissues. Instead, they stimulate the body’s own cells, so improvements are gradual, depending on the cells’ response. The results general emerge after a series of three treatments spaced 4–6 weeks apart.

For patients who need instant correction or prefer a single-session treatment, hyaluronic acid dermal fillers remain the more appropriate choice.